Dynamic Dosing Of Resveratrol Recommended For Optimal Health SAN DIMAS, Calif., June 3
SAN DIMAS, Calif., June 3 /PRNewswire/ -- While an earlier published
rodent study showed that ultra-high doses of resveratrol (1565 milligram human
dose), equivalent to 1500 bottles of wine or many dietary supplement capsules,
successfully overcame the adverse effects of a high-fat diet, the lowest dose
that genetically mimics a calorie restricted diet went undetermined, till now.
(Photo: http://www.newscom.com/cgi-bin/prnh/20080603/LATU039)
(Photo: http://www.newscom.com/cgi-bin/prnh/20080422/LATU004)
Now an authoritative gene array study, conducted by researchers at the
William S. Middleton Memorial Veterans Hospital and Lifegen Technologies in
Madison, Wisconsin, shows that a dose of resveratrol (rez-vair-aw-trawl) ~343
milligrams per day (4.9 mg per kilogram of body weight) produces a gene
activation profile similar to a calorie restricted diet. Supra-high doses
(greater than 500 milligrams) are not required and may produce side effects.
[PLOS1, June 2008 available online http://www.plosone.org/home.action ]
Both calorie restriction and resveratrol have been shown to prolong the
life of all life forms, ranging from single-cell organisms (yeast cells) to
more complex forms of life (fruit flies, roundworms) and warm-blooded mammals
(laboratory rats).
Consumers never heard that a far lower human equivalent dose than
1565 milligrams (~360 milligrams) was employed with undisclosed success in a
landmark rodent study published in 2006. The lower-dose data were never
published. [Resveratrol improves health and survival of mice on a
high-calorie diet. Nature 2006 Nov 16; 444: 337-42]
Drawbacks of supra-high doses
"Once mega-doses of resveratrol (more than 500 mg) began to be employed,
side effects like anemia, Achilles heel tendonitis, anxiety reactions,
numbness in the fingers, began to be reported," says Bill Sardi, spokesperson
for Longevinex(R) (long-jev-in-ex), a leading brand resveratrol dietary
supplement. "This is probably because resveratrol is a copper chelator and
excessive chelation will impair the availability of copper which is needed for
collagen formation and nerve regeneration," he says. "Resveratrol is
relatively safe, but not absolutely safe at any dosage. There are drawbacks,"
he adds.
Some online suppliers of resveratrol pills, who have no medical training,
irresponsibly recommend up to 7000 milligrams of resveratrol a day. There is
also evidence that supra-high dose resveratrol inhibits the absorption of
folic acid (vitamin B9), an essential nutrient needed for DNA repair.
[European Journal Nutrition 46: 329-36, 2007] High doses have not been tested
in humans for long-term use.
Advertising claims by resveratrol supplement makers that their pills exert
greater stimulation of the Sirtuin 1 DNA-repair gene should also be regarded
with caution since an animal study shows over-stimulation (greater than 7.5
fold) of this gene induces heart failure in animals. [Circulation Research
2007; 100: 1512-21]
Not just resveratrol
The health and longevity benefits of red wine are not easily explained by
the low dose of resveratrol provided in a glass of wine, but are more easily
explained by the total milligrams of polyphenolic molecules (resveratrol,
quercetin, catechin, kaempferol, ferulic acid), about 60 milligrams per glass
of aged red wine, says Sardi. The healthy range for red wine drinking is 3 to
5 glasses, or about 180 to 300 milligrams of polyphenols. Dietary supplements
should provide about the same dosage range. Mega-doses are not required and
may be problematic.
Red wine is a fermented concentrate of grape skin which provides an array
of beneficial molecules which magnify its effect, says Sardi. A resveratrol-
based nutraceutical matrix that closely mimics the effect of red wine without
the alcohol, calories and preservatives is what Longevinex(R) is.
Factors that determine safe dosage
Age, gender, diet and iron stores determine the resveratrol dosage
required for optimal health. Red wine resveratrol pills are not appropriate
for growing children or menstruating females, who have higher demand for
minerals. However, Sardi explains that some consumers may benefit from a
higher loading dose and a lower long-term maintenance dose.
Consumers need to recognize the health benefits of resveratrol and related
molecules emanate from their mineral chelating (removal) properties, which
then influence the genome, says Sardi. [BMC Genomics 8: 379, 2007; Biochmica
Biophysica Acta 1619: 113-24, 2003] Middle-aged males and postmenopausal
females have accumulated stores of excess iron and calcium which can be
removed by natural mineral chelators, like those provided in Longevinex(R).
"A middle-aged male will typically have a higher load of stored iron and
calcium and may benefit from a higher loading dose of mineral chelators, to
speed along their removal, followed by a lower dose for long-term
maintenance," says Sardi. He also suggests a relatively low iron and calcium
diet to accompany a dietary supplement regimen intended to produce longevity.
Humans live longer in countries where calcium and iron intake are low, such as
Japan, he says.
When does aging begin?
Sardi explains a theory of why molecules like resveratrol slow the aging
process. He says human aging begins only after full childhood growth is
achieved. Until then, there are no observable aging changes in living cells.
But once childhood growth ceases, iron, copper and calcium, which were
directed towards building new bone and red blood cells, now begin to slowly
accumulate, progressively "rusting and calcifying" cells and tissues.
Sardi says males universally age faster and have shorter life spans
because they do not have inborn mechanisms to control the accumulation of iron
and calcium as do menstruating females. By age 40 a male will have twice the
iron and calcium load as an equally-aged female and experience double the rate
of diabetes, cancer and heart disease.
Longevinex(R) uniquely provides a unique matrix of nutraceuticals which
both directly and indirectly control iron and calcium utilization in the human
body.
Longevinex' applied-for-patent (file # United States Patent Office
20050158376, filed Oct. 25, 2004) describes a nutraceutical matrix designed to
enhance the absorption, bioavailability, and molecular stability of
resveratrol in a manner similar to a proprietary resveratrol drug now
undergoing human clinical investigation. For more information about
Longevinex(R) visit http://www.longevinex.com .
SOURCE Resveratrol Partners LLC
