BRISBANE, Australia, June 29 /PRNewswire-FirstCall/ -- Progen Pharmaceuticals Limited today announced the establishment of an international clinical advisory board to support the clinical development and commercialization of PI-88 in the treatment of post- resection liver cancer.
The advisory board consists of nine world-renowned thought leaders in the fields of oncology and liver cancer: Professor Rene Adam, Hopital Paul Brousse, France; Professor Pei-Jer Chen, National Taiwan University, Taiwan; Professor S. Gail Eckhardt, University of Colorado, United States; Professor Philip Johnson, University of Birmingham, United Kingdom; Professor Sung-Gye Lee, Ulsan University Medical School, Republic of Korea; Professor Ronnie Poon, Queen Mary Hospital, Hong Kong; Professor Myron Schwartz, Mount Sinai School of Medicine, United States; Professor William Sievert, Monash University, Australia; and Professor Tadatoshi Takayama, Nihon University School of Medicine, Japan. Progen expects to announce additional appointments to this board over the coming months.
"It is a significant achievement that some of the most well-respected researchers and practitioners in the field of liver cancer have agreed to join our clinical advisory board. The board will provide essential expertise and invaluable counsel, and we consider it a privilege to have these individuals involved with the development of PI-88," said Justus Homburg, Chief Executive Officer of Progen.
He further commented, "Appointing this board is a critical part of the preparation for our Phase 3 trial in various regions around the world. We remain on track to implement our aggressive timeline of launching the trial in the second half of this year. We have short-listed proposals from leading Contract Research Organizations (CROs) that will assist us in the operational tasks in the trial and we are already working with members of our advisory board to identify clinicians and hospitals worldwide that will be involved in the trial."
Clinical Advisory Board Member Biographies
-- Professor Rene Adam, MD, PhD, Hopital Paul Brousse, France
Professor Rene Adam heads the Centre Hepatobiliaire at Paul Brousse
Hospital in Villejuif, just outside Paris, and is a Professor of
Surgery at the Universite de Paris-Sud. He is one of the leading
researchers in Europe in the field of upper GI surgery, with interests
focusing on liver transplant and resection. He is Custodian of the
European Liver Transplant Registry and serves on the Editorial Board of
The Oncologist. He is the author of over fifty peer-reviewed
publications in the field of liver surgery and is frequently invited to
speak at international meetings on this topic.
-- Professor Pei-Jer Chen, MBBS, PhD, National Taiwan University, Taipei,
Taiwan
Professor Chen was appointed Director of the Hepatitis Research Center
at the National Taiwan University Hospital in Taipei in 2001. His
research interests focus on the virology of infectious hepatitis,
especially the replication of hepatitis D, and on the molecular biology
of liver cancer. Professor Chen's clinical research covers the natural
history of chronic viral hepatitis and hepatocellular carcinoma, and
also explores new therapies and trials for both diseases.
From 2001 to 2006, he was a member of the editorial board of the
prestigious journal Hepatology, and he has also been the recipient of
numerous academic prizes and awards, including Outstanding Research
Awards from 1991 through 1999 from the National Science Council in
Taiwan and the Award for Distinguished Biomedical Research from the Hou
Jin Dwei Foundation of Taiwan. In 2000, Professor Chen was appointed
International Research Scholar in Infectious Diseases by the Howard
Hughes Medical Institute for a period of five years. He has authored or
co-authored over 100 articles in the areas of hepatitis and
hepatocellular carcinoma, and he has presented on these topics at
regional and international conferences.
Professor Chen completed his medical training at the National Taiwan
University, and subsequently undertook a PhD in virology at the
University of Pennsylvania.
-- Professor S. Gail Eckhardt, MD, University of Colorado, Denver,
Colorado
Professor Eckhardt is currently Professor of Medicine at the University
of Colorado Health Sciences Center in Denver, Colorado, where she also
serves as Director of the Developmental Therapeutics and GI
Malignancies Programs and Division Head of Medical Oncology. Prior to
joining the University of Colorado, Professor Eckhardt served as
Associate Director of Clinical Research, and as Director of the Drug
Development Fellowship Training Program at the Institute for Drug
Development, Cancer Therapy and Research Center, in San Antonio, Texas.
Professor Eckhardt is a highly-experienced clinical trial investigator
and serves on the Board of Directors for the American Society of
Clinical Oncology (ASCO). In addition, she is an Associate Editor of
the Journal of Clinical Oncology, Clinical Cancer Research, and
Investigational New Drugs. Her research interests focus on GI
malignancies and she has published over 60 manuscripts in this area.
Professor Eckhardt received her medical degree from the University of
Texas Medical Branch in Galveston, Texas.
-- Professor Philip Johnson, MD, FRCP, University of Birmingham, United
Kingdom
Professor Johnson is currently Professor of Oncology and Translational
Research at the Cancer Research UK Institute for Cancer Studies at the
University of Birmingham.
Professor Johnson trained in medicine at the University of Manchester.
He completed residencies at several London hospitals, including Guy's
Hospital and the Royal Marsden. Professor Johnson developed his
interest in hepatobiliary cancer as a Research Fellow at the Institute
of Liver Studies, King's College Hospital, London, where he
subsequently became Assistant Director. In 1992, he was appointed to
the Chair of Clinical Oncology at the Chinese University of Hong Kong
where he also became Director of the Cancer Centre. During his time in
Hong Kong, Professor Johnson developed his current research interests
in molecular biomarkers of cancer, while furthering his studies on new
approaches to the treatment of liver cancer.
He has written over 270 peer-reviewed papers, 43 book chapters and a
number of other publications. Professor Johnson is frequently sought as
a speaker at international conferences and is widely recognized as a
leading authority on the medical oncology of liver cancer.
-- Professor Sung-Gye Lee, MD, PhD, FACS, Ulsan University Medical School,
Seoul, Korea
Professor Lee is widely recognized as a pioneer of liver transplant
surgery, having performed Korea's first pediatric and adult living-
donor liver transplantation in 1992 and 1997, respectively. In
addition, he performed the world's first dual living-donor liver
transplantation in 2000, and the modified right-lobe LDLT in 1998. From
1986 to 1987, Professor Lee had a visiting fellowship at Boston, Lahey
Clinic and New England Deaconess Hospital.
Professor Lee's major interests are in resection and transplantation of
hepatocellular carcinoma, and his series of patients is the largest in
the world. His future interests are primarily concerned with the
development of new, highly-effective chemotherapeutic agents.
Professor Lee completed his internship and surgical residency at the
Seoul National University Hospital, and his MD, PhD at the Seoul
National University Medical School.
-- Professor Ronnie Poon, PhD, MD, Queen Mary Hospital, Hong Kong
Professor Poon has served as Professor of Surgery at the Queen Mary
Hospital in Hong Kong since 2001. Previously, Professor Poon worked as
a Surgical Resident at the University of New South Wales, at St.
Vincent's Hospital in Sydney, and at Kwong Wah Hospital as Medical
Officer in Hong Kong. He has published several academic papers focused
on surgery and cancer research.
Professor Poon holds a Masters of Surgery and a Doctor of Philosophy
from the University of Hong Kong. He has furthered his professional
qualifications with numerous 'Royal College of Surgeon' awards at local
and international Academic Institutions.
-- Professor Myron Schwartz, MD, FACS, Mount Sinai School of Medicine, New
York, New York
Professor Schwartz is currently Director of Surgical Oncology and
Associate Director of Liver Transplantation at Mount Sinai, where he
oversees the hepatobiliary cancer unit. He came to Mount Sinai in 1981,
completed residencies in general and vascular surgery, and joined the
faculty in 1987. Professor Schwartz's principal research interest is in
primary liver cancer and his research program has been funded by the
NIH through a K24 Career Development Award entitled, "Systematic
Integration of Patient-Oriented Research into the Clinical Pathway for
Hepatocellular Carcinoma."
Professor Schwartz worked with Charles Miller, MD, to establish the
Liver Transplant Program at Mount Sinai in 1988, and since 1990 he has
devoted his career to hepatobiliary surgery and transplantation. He has
published over 200 papers in peer-reviewed journals, as well as 15 book
chapters. Professor Schwartz is one of the country's leading experts on
primary liver cancer, and lectures frequently on the subject both in
the U.S. and around the world.
-- Professor William Sievert, MD, FRACP, Monash University, Melbourne,
Australia
Professor William Sievert is the Director, Gastrointestinal and Liver
Unit, Southern Health, which incorporates two large teaching hospitals
- the Monash Medical Centre and Dandenong Hospital. He is also a
tenured professor in the Faculty of Medicine, Nursing and Health
Sciences at Monash University.
Professor Sievert has an interest in liver disease and directs an
active clinical research unit comprising physician-scientists, clinical
research nurses and research students. The Clinical Research Unit has
been continuously active for over 10 years and regularly contributes to
international trials of new antiviral agents for hepatitis B and C, in
addition to developing and leading national investigator-initiated
studies. Professor Sievert also directs a basic research laboratory
investigating mechanisms of liver injury and hepatic fibrogenesis with
a translational focus on identification and development of potential
hepatic antifibrotic agents.
Professor Sievert has been active in medical education, including the
development of new undergraduate and graduate medical curricula at
Monash University.
-- Professor Tadatoshi Takayama, MD, Nihon University School of Medicine,
Tokyo, Japan
In 2001, Professor Takayama was appointed Professor and Chairman of the
Department of Digestive Surgery at the University of Nihon School of
Medicine.
Dr. Takayama is a prolific academic author with over 350 papers
published in international scientific journals. He serves on the
Editorial Board of several prestigious international journals,
including Hepato-Gastroenterology, the Japanese Journal of Clinical
Oncology, the Journal of Gastroenterology and Hepatology, and the World
Journal of Gastroenterology. Dr. Takayama is also the Editor of the
Journal of Cancer Research and Clinical Oncology. He is the recipient
of numerous academic prizes and awards, including, in 2001, the
Hepatology Research Award of the Japan Society of Hepatology. In
addition, Dr. Takayama is a frequent speaker at international
conferences.
Dr. Takayama trained in medicine at Nihon University School of Medicine
in Tokyo. His postgraduate surgical training was undertaken primarily
at the National Cancer Center Hospital, where he served as Head Surgeon
from 1989 to 1995.
About Progen: Progen Pharmaceuticals Limited is an Australian-based globally focused biotechnology company committed to the discovery, development and commercialization of small molecule therapeutics primarily for the treatment of cancer.
This press release contains forward-looking statements that are based on current management expectations. These statements may differ materially from actual future events or results due to certain risks and uncertainties, including without limitation, risks associated with drug development and manufacture, risks inherent in the extensive regulatory approval process mandated by the United States Food and Drug Administration and the Australian Therapeutic Goods Administration, delays in obtaining the necessary approvals for clinical testing, patient recruitment, delays in the conduct of clinical trials, market acceptance of PI-88, PI-166 and other drugs, future capitals needs, general economic conditions, and other risks and uncertainties detailed from time to time in the Company's filings with the Australian Stock Exchange and the United States Securities and Exchange Commission. Moreover, there can be no assurance that others will not independently develop similar products or processes or design around patents owned or licensed by the Company, or that patents owned or licensed by the Company will provide meaningful protection or competitive advantages.
Progen Pharmaceuticals Limited
CONTACT: Justus Homburg, +61-7-3842-3333, justush@progen-pharma.com, or
Noreen Dillane, +61-7-3842-3333, noreend@progen-pharma.com, both of Progen
Pharmaceuticals Limited; or Media and Investor Relations Australia, Rebecca
Piercy, +61-2-9237-2800, +0422-916-422, rpiercy@bcg.com.au, or Rebecca Wilson,
+61-417-382-391, rwilson@bcg.com.au, both of Buchan Consulting; or Media
Relations USA, Robert D. Stanislaro, +1-212-850-5657,
robert.stanislaro@fd.com, or Investor Relations USA, Evan Smith,
+1-212-850-5606, evan.smith@fd.com, both of Financial Dynamics
